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JN.1, a new COVID variant, becomes dominant in Oregon

gloved hands holding a test tube and swabs.
Mufid Majnan
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JN.1 may more easily evade the immune system than other variants, but its infections do not appear to be more severe or deadly, according to Dr. Paul Cieslak with the OHA.

A new COVID variant has become dominant in Oregon, according to data from the state Health Authority.

JN.1 is an Omicron subvariant which was first detected in August. The CDC projects that it may now make up as many as two-thirds of U.S. cases.

In Oregon, the variant reached a 58% share in mid-December, according to the most recently sequenced samples from the OHA. And state officials expect that those figures will continue rising.

“It's pretty different from the variants that we've been seeing lately,” said Dr. Paul Cieslak, the OHA’s Medical Director for Communicable Diseases and Immunizations. “And so possibly it's evading some of the immunity that we had.”

The variant’s emergence in Oregon has coincided with rising cases and hospitalizations. Cieslak said there’s no firm evidence JN.1 has contributed, but it would make sense.

“The fact that this strain is spreading so much more rapidly means that we're more likely to get it and possibly get severe disease from it," said Cieslak.

Cielsak said JN.1 has around 30 genetic differences from the XBB lineage common in Oregon. In comparison, he said variants within that family often have just one or two differences.

He said since the current monovalent booster is based on XBB, that may weaken immunity. However, he said getting vaccinated is still the public’s best option to protect themselves.

"When it comes to preventing the more severe cases of disease," he said, "the immunity that we have based on our exposure to several previous variants and vaccination is still holding up fairly well.”

Cieslak said there’s no evidence that JN.1 leads to infections that are more severe or deadly. The World Health Organization has declared it a "variant of interest," but said it poses a low additional threat to public health.

Center for Disease Control
The lineage of COVID-19 variants. B.1.1.529 is more commonly referred to as Omicron.

Nathan Wilk joined the KLCC News Team in 2022. He is a graduate from the University of Oregon School of Journalism and Communication. Born in Portland, Wilk began working in radio at a young age, serving as a DJ and public affairs host across Oregon.